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Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A

2012 (PMID 22129598), which introduced the HGF-dimerization framing, was retracted in 2025 (retraction notice PMID 40312092)

Dihexa has not been tested in mood paradigms Conclusion# Dihexa and PE-22-28 both represent genuinely novel approaches to nootropic pharmacology, targeting pathways (HGF/c-Met and TREK-1, respectively) that are largely unexplored in cognitive enhancement research

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